To determine whether MBTPS1 is directly involved in proliferation of colon cancer cells, we treated two human-derived epithelial adenocarcinoma cells, HT-29 and HCT-116, with a MBTPS1 chemical inhibitor (PF-429242) (36) and measured the effect on cell proliferation. The gene discussed is MBTPS1; the disease is malignant colon neoplasm.