MDFI and cancer: We mapped the RTK-RAS pathway and the WNT pathway of the first two pathways in the high MDFI group as waterfalls, respectively, LUAD-derived Wnts increase the proliferation/stemness potential of cancer cells, and LUAD cells use paracrine Wnt1 signaling to induce immune resistance, which could provide a new pathway therapeutic option for LUAD with high MDFI expression (55–57).