It has been revealed that GAS1, was directly modulated by the transcription factor FOXM1, impairs cell invasion, proliferation and aerobic glycolysis of colorectal cancer both in vitro and in vivo, through inhibiting EMT and the Warburg effect by AMPK/mTOR/p70S6K axis (59); similarly, GAS1 acts as a tumor suppressor in gastric and breast cancers, etc (60, 61). This evidence concerns the gene MTOR and breast carcinoma.