reveal that circ-ERBIN promotes the proliferation, invasion, angiogenesis and metastasis of colorectal cancer (CRC) through targeting miR-138-5p and miR-125a-5p, and thereby synergistically boosts the expression of the 4EBP-1, which next reinforces HIF-1α protein expression and activation of HIF-1α pathway (6). The gene discussed is HIF1A; the disease is colorectal carcinoma.