also illustrated that monocyte/macrophages polarization toward M2 phenotype, LAMP3 + DC subgroup recruiting regulatory T cells, and inflammatory cancer-associated fibroblasts (iCAFs) in the tumor region, all potentially involve in the formation of an immune-suppressive TME and tumor progression, which is significantly associated with poor prognosis of BCa patients (68). This evidence concerns the gene LAMP3 and neoplasm.