Recent researches showed that circ-VANGL1 was identified as a sponge of miR-605-3p targeting VANGL1 In BCa (10), Circ-ZEB1.33 via ponging miR-200a-3p and upregulating CDK6 in human hepatocellular carcinoma (11), circ_0020710 by targeting miR-370-3p/CXCL12 axis in melanoma (9), and circ0093740 through modulating miR-136/145-DNMT3A axis in Wilms Tumor (12), consequently contributes to cancer cells growth, migration, invasion or metastasis. This evidence concerns the gene VANGL1 and melanoma.