CD8A and cancer: According to the 7 immune-infiltration algorithm analysis (TIMER, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, MCPCOUNTER, XCELL and EPIC), a heatmap of 45 significant differences at the level of immune cells (sigDICs) in the high vs. low risk groups (Wilcoxon test, P < 0.01) is presented as Figure 7A, and these differential immune cells including CD8+ T cells, cancer associated fibroblast, macrophage M2, neutrophils, myeloid dendritic cell and endothelial cell, etc. Meanwhile, we performed the spearman’s correlation analysis (P < 0.01) between riskscore and immune-infiltration cells (Figures 7C, D).