Both homotypic adhesion of tumor cells to form clusters and the subsequent binding of these to the endothelium prior to extravasation and tumor spread have both been shown to be mediated by the TFag-Gal-3 interaction (Glinsky et al., 2001; Takenaka et al., 2002; Glinsky et al., 2003; Yu et al., 2007; Zhao et al., 2010; Glinskii et al., 2012; Reticker-Flynn and Bhatia, 2015; Rodriguez et al., 2015). The gene discussed is LGALS3; the disease is neoplasm.