Mechanistically, the TFag has been unequivocally shown to interact with the CBP Galectin-3, a β-galactoside binding protein that interacts both intra- and extracellularly with many glycoproteins, is overexpressed in a variety of tumors and whose expression is directly correlated with tumor aggressiveness and metastasis (Takenaka et al., 2002). The gene discussed is LGALS3; the disease is neoplasm.