LDLRAD3 and familial pancreatic carcinoma: High expressions of circ_0007534, circ-ADAM9, circ-ASH2L, circ-LDLRAD3, circ -PDE8A (hsa_circ_0036627) have each been independently associated with worse prognosis in PDAC [29]. Yang et al. also confirmed that circ-LDLRAD3 was significantly upregulated in pancreatic cancer tissues and plasma and that a high level of circ-LDLRAD3 was positively associated with tumor venous invasion (p=0.025) and lymphatic metastasis (p=0.014).