ADAMTS1 and familial pancreatic carcinoma: Eissa et al. used circulating cell-free DNA (cfDNA) from a large cohort of patients at different stages of pancreatic cancer and an age-matched normal group to study DNA methylation of genes ADAMTS1 and BNC1 to determine the usefulness of this two-gene panel as a non-invasive biomarker set for the early detection of pancreatic cancer.