Studies have proved that inflammation associated with elevated levels of resistin and leptin has a significant role at the beginning of the mechanism of inflammation and leads to the advancement of atherosclerotic disease [13], as a known factor that CRP is an important marker determining the degree of inflammation, this elevated levels of resistin and leptin, in turn, induces the production of CRP in coronary endothelial cells and this CRP promotes vascular thrombosis that might be involved in the acute coronary syndrome pathophysiology process [13]. Here, RETN is linked to acute coronary syndrome.