IL1B and serum lipopolysaccharide activity: Studies have also shown that electroacupuncture “Hegu” (LI4) activates muscarinic acetylcholine receptor signals in the brain through somatic afferent, and then activates the efferent vagus nerve and splenic nerve, exerting an anti-inflammatory effect, reducing TNF, IL-1β, and IL-6 levels and improving survival rate in endotoxemia model rats (Song et al., 2012).