Hyperglycemia results in the impairment of endothelial cells, reducing the generation of the vasodilator NO, thus favoring a vasoconstrictive state through the increase in vasoconstrictors and pro-thrombotic mediators, endothelin-1 (ET-1) and thromboxane A2 (TXA2). The gene discussed is EDN1; the disease is Hyperglycemia.