Feeding of fisetin-containing diet to Drosophila flies expressing pathogenic human Htt (w elav:Gal4/w; P{UAS-Httex1p Q93}/+) (Httex1p Q93) enhanced ERK phosphorylation and activation, resulting in ∼25% diminution of neurodegeneration, suppression of symptoms of HD and increased 77% of overall survival (Maher et al., 2011a). Here, HTT is linked to Huntington disease.