IFNG and polycystic ovary syndrome: Many studies have shown that chronic low-grade, increase in pro-inflammatory cytokines, decrease of anti-inflammatory cytokines, insulin resistance, hypersensitivity of Helper T-cells (Th1); Th1-type immunity and the ratio of Th1 to Th2 cells, as well as Th1 cytokines such as IFN-γ and IL-2 are increased during immune reactions in PCOS patients (Qin et al., 2016) and hyperandrogenism play a crucial roles in PCOS pathogenesis (González et al., 2014a).