BMP2 and polycystic ovary syndrome: The theca cells in the ovary proliferate rapidly and increased androgen production in PCOS (Bremer, 2010; Zhang et al., 2012), it has been reported that BMP-2 can inhibit the proliferation of different cells in vitro (Hardwick et al., 2004; Chen et al., 2012; Zhang et al., 2012).