In this context, it is well known that angiogenesis is essential for tumor progression, T98G, U373, and U87 glioma cell lines have been revealed the p38 MAPK and JNK constitutively activated contributing angiogenesis induced by the vascular endothelial growth factor (VEGF) release (Yoshino et al., 2006). This evidence concerns the gene VEGFA and central nervous system cancer.