MX2 and glioblastoma: Wang et al. (2019) have been shown that MXB (also named MX2) protein, a component of the innate immune response, is downregulated in GBM cells. This fact corroborates to tumor progression once MXB overexpression decrease the cell proliferation, invasion, and migration due to the decrease in ERK1/2 and p38 phosphorylation/activation, and Nf-κB levels (Wang et al., 2019).