TGFB1 and cardiac hypertrophy: Thus, it was found that the gene expression of IL-6, a pro-inflammatory molecule known to be involved in the cardiac hypertrophy, was significantly increased in hiPSC-CMs stimulated with AngII and TGF-β1 for 48 h compared to unstimulated cardiomyocytes in the control position (1.81-fold, *p < 0.05) (Figure 8D).