In this study we investigated the therapeutic potential of EVs released by human MSCs isolated from adipose tissue (EV-ADSCs) or bone marrow (EV-BMMSCs) on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) stimulated with Ang II and TGF-β1 as an in vitro model for cardiac hypertrophy. Here, TGFB1 is linked to cardiac hypertrophy.