Papers published recently evidenced that upregulation of Ang II stimulates TGF-β1 expression in the myocardium revealing the close interaction between Ang II and TGF-β mediated responses in the pathological cardiac hypertrophy (Schultz Jel et al., 2002; Rosenkranz, 2004; Bujak and Frangogiannis, 2007). Here, AGT is linked to cardiac hypertrophy.