Also, in a paper we have recently published we showed that the treatment with EV-ADSCs or EV-BMMSCs alone or in combination with Smad2/3siRNA induced a significant decrease of expression of structural and inflammatory markers COL1A1, α-SMA, Cx43, VCAM-1 and MMP-2 at hypertensive-hyperlipidemic hamster that mimics human atherosclerosis (Ioana Karla Comarița et al., 2022). This evidence concerns the gene VCAM1 and atherosclerosis.