Our in vitro study showed that the presence of EV-ADSCs or EV-BMMSCs in the hiPSC-CM culture along with hypertrophic stimuli, AngII and TGF-β1, reduced the protein expressions of hypertrophic specific markers, such as ANF, MIF, cTnI, COL1A1, and the gene expressions of IL-6 molecule involved in inflammatory process associated with cardiac hypertrophy and transcription factors SMAD2, SMAD3, cJUN, cFOS with role in cardiomyocyte hypertrophic response. Here, SMAD2 is linked to cardiac hypertrophy.