NURR1 expression was shown to be considerably lower in Parkinson’s sufferers, according to research, NURR1 has the ability to induce differentiation, maturity, and growth of dopaminergic neurons, protection of dopaminergic neurons, and reduction of inflammation-induced necrosis (Li et al., 2019; Rahman et al., 2022b). This evidence concerns the gene NR4A2 and Parkinson disease.