mTORC2 promotes cell survival by activating protein kinase B (Akt), regulating cytoskeletal dynamics via activation of PKCα, and regulating ion transport and proliferation via phosphorylation of SGK1. mTOR signaling defects are associated with many pathological conditions, including cancer, cardiovascular disease, and diabetes (Szwed et al., 2021). The gene discussed is AKT1; the disease is cancer.