In summary, our findings demonstrate that the ethanolic extract of O. syriacum (OSEE) exhibits potent anti-tumor growth and anti-metastatic effects on the aggressive phenotype of TNBC by modulating the processes of cell adhesion, migration, invasion, and angiogenesis through the inhibition of STAT3 signaling and activation of p38 MAPK signaling pathways. The gene discussed is STAT3; the disease is neoplasm.