Several mechanisms such as hypoxia, immunosuppressive cytokine production, reduced T-cell proliferation, and effector response, activation of FoxP3 + regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSC) mediate the immunosuppression in glioblastoma (Mirghorbani et al., 2013; Razavi et al., 2016). This evidence concerns the gene FOXP3 and glioblastoma.