In this paper, the MTHFR gene C677 T polymorphism, changes in plasma Hcy level and its role in the occurrence of hypertension in elderly female patients with H-type hypertension are studied, aiming to explore the mutation characteristics of MTHFR C677 T in elderly female population, thus, providing reference data for the prevention and treatment of such patients with H-type hypertension and individualized treatment. Here, MTHFR is linked to hypertensive disorder.