All HCC patients using this database were analyzed and it was found that the expression levels of HGFAC (HR = 0.65, P=0.0149), PROZ (HR = 0.59, P=0.0027), and SLC22A1 (HR = 0.52, P=0.0002) in patients with hepatocellular carcinoma were correlated with the OS in patients with HCC. This evidence concerns the gene PROZ and hepatocellular carcinoma.