The Prunella vulgaris polysaccharide fraction (PPV) significantly reduced the antigen expression of both ACV-sensitive HSV and HSV-1 ACVr strain DM2.1 (ACV-resistant with TK deficiency) according to immunostaining and flow cytometric analyses of HSV-1 and HSV-2 antigens (Chiu et al., 2004). This evidence concerns the gene TKT and hyperinsulinemic hypoglycemia, familial, 4.