CD3D and colorectal cancer: ACTR3B (actin-related protein 3B) protein expression has been linked to colorectal cancer invasion and proliferation (Yu and Zhang, 2020), it is part of a complex with CAPG and CD3D that interacts with several HIV proteins (Zhang et al., 2019) and its expression aids SARS-CoV-2 binding and intracellular processing (Kalejaiye et al., 2022).