Studies have shown that VEGFA plays an important role in spare nerve injury- (SNI-) induced neuropathic pain, which is mediated by enhancing the expression and colocalization of VEGFA, p-AKT, and TRPV1 in a SNI-induced neuropathic pain model, which also improves expression of VEGFA, VEGFR2, p-AKT and TRPV1 in the spinal cord [27–29]. This evidence concerns the gene AKT1 and neuropathic pain.