PI3K-Akt signaling pathway involved 34 (15.89%) gene targets, microRNAs in cancer and proteoglycans in cancer; Ras signaling pathway involved 23 (10.75%) gene targets; neuroactive ligand-receptor interaction involved 22 (10.28%) gene targets; prostate cancer, Rap1 signaling pathway, Alzheimer disease, and MAPK signaling pathway involved 20 (9.35%) gene targets and so on. This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.