1.Allergic disease: positive SPT response at 0–2 Y, specific IgE >0.7 kU/L at 0–5 Y2.Sensitization: positive SPT response and/or specific IgE >0.7 kU/L at 0–2 and 0–5 Y3.Allergic disease: all eczema at 0–2 and 0–5 Y, IgE-associated eczema at 0–2 Y, IgE-associated asthma and rhinitis at 0–2 and 0–5 Y. The gene discussed is IGHE; the disease is allergic disease.