In agreement with previous NB-SCI studies (8, 10, 12), the presenting features of our patients differed from those expected in an overall NB population (11, 30, 31) for several characteristics: younger age (median, 11 vs. 16–19 months), greater frequency of thoracic primary tumors (49 vs. 20–30%) and localized disease (66 vs. 44–53%), and lower proportion of MYCN gene amplification (7 vs. 15–20%). Here, MYCN is linked to neuroblastoma.