The mRNA expressions of TNF-α, IL-6, and angiopoietin-like 4 (Angptl4), which are involved in insulin resistance (Watanabe et al., 2008; Trayhurn and Alomar, 2015), were shown to be higher in the adipose tissue of mice from the P. gingivalis-administered group. This evidence concerns the gene IL6 and Insulin resistance.