To confirm the role of FOXO1 and STAT3 and its relation to ITGB6 expression in vivo, we performed immunohistochemistry to detect the expression of ITGB6, FOXO1, and STAT3 using sequencing slices from healthy human gingival tissue and gingival epithelium of patients with periodontitis. Here, ITGB6 is linked to periodontitis.