A complete laboratory investigation looking at the key functions of the VWF protein is required for a complete diagnosis and classification of VWD and to establish the best treatment modality13: VWF:Ag, FVIII:C, VWF:ristocetin cofactor activity (VWF:RCo) and/or VWF:GPIb binding activity (VWF:GPIb), VWF collagen binding capacity (VWF:CB), VWF propeptide (VWFpp), VWF:FVIII binding capacity (VWF:FVIIIB), VWF multimeric (VWF:MM) analysis, and genetics.2, 8The use of an algorithm of all available laboratory tests for the investigation of suspected VWD can improve its diagnosis and classification. This evidence concerns the gene F8 and von Willebrand disease (hereditary or acquired).