VWF and von Willebrand disease (hereditary or acquired): A complete laboratory investigation looking at the key functions of the VWF protein is required for a complete diagnosis and classification of VWD and to establish the best treatment modality13: VWF:Ag, FVIII:C, VWF:ristocetin cofactor activity (VWF:RCo) and/or VWF:GPIb binding activity (VWF:GPIb), VWF collagen binding capacity (VWF:CB), VWF propeptide (VWFpp), VWF:FVIII binding capacity (VWF:FVIIIB), VWF multimeric (VWF:MM) analysis, and genetics.2, 8The use of an algorithm of all available laboratory tests for the investigation of suspected VWD can improve its diagnosis and classification.