EREG and leukoencephalopathy with calcifications and cysts: In contrast, mutations in the APC, KRAS, SMAD4, and TP53 genes, amplification of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), and overexpression of the EGFR ligands epiregulin (EREG) and antifiregulin (AREG) were more prevalent in LCC [16].