They used mouse and human models with time-series single-cell transcriptomic analysis to reveal the dynamic evolution of MYC-driven SCLC isoforms, finding that in neuroendocrine cells, MYC activated Notch to dedifferentiate tumor cells, promoting the temporal transition of SCLC from ASCL1 + to NEUROD1 + to YAP1 + state. The gene discussed is ASCL1; the disease is small cell lung carcinoma.