Overall, we used information from up to 1,600 samples of multiple LUAD cohorts to represent the important role of MYC signaling in LUAD from multiple dimensions of transcriptional profile expression, genomic instability, genetic alteration and regulation, immune microenvironment landscape, cell differentiation, and disease survival.This provides a valuable reference for deeply revealing the mechanism of cancer-promoting action of MYC in LUAD. This evidence concerns the gene MYC and cancer.