Given the non-negligible and important role of MYC in cancer cell growth, proliferation, and differentiation, this study innovativelyused LUAD multi-omics data from multiple cohorts to systematicallyinvestigate the relevance of transcriptional profile expression, genome instability, genetic alteration and regulation, immune microenvironment landscape, cell differentiation, and disease survival in Halkmark MYC target V1 gene sets by integrating bulk and single-cell RNA sequencing data. This evidence concerns the gene MYC and cancer.