CDK8 and neoplasm: The results showed that CDK8 and CDK16 have the potential to be prognostic biomarkers for EC and therefore we are more interested in CDK8 and CDK16. In previous studies, researchers have used in vitro experiments to demonstrate that CDK8 expression is higher in EC tissues than in adjacent normal tissues and that CDK8 acts as a tumor suppressor in EC (Gu et al., 2013).