IL17A and neoplasm: Recent work by Panagiota Mamareli indicated that de novo synthesis of fatty acids is necessary for the differentiation of the Th17 phenotype (Mamareli et al., 2021), In contrast, Ran You et al. observed that TIL in early-stage NSCLC was biased towards IL17A expression, whereas Th17 cells were reduced in tumor-infiltrating regional lymph nodes in advanced NSCLC (You et al., 2018).