Mouse models with defects in the angle of the ET have OM, including Eya4, Fbxo11jf/+, and Sh3pxd2b mice (Hardisty et al., 2003; Depreux et al., 2008; Yang et al., 2011), while defects in ET muscles have also been linked to syndromic OM (Fuchs et al., 2015). Here, EYA4 is linked to ocular melanoma.