Table 3 depicts the results of the Cox proportional hazards model which modelled the relationship between RR-TB and 12-week mortality. RR-TB was significantly associated with 12-week mortality (hazard ratio 1.88; 95% confidence interval 1.07–3.29; P = 0.03) when adjusting for CRP, CD4 count, HIV viral load, creatinine, sodium, PG, haemoglobin, weight, GCS, hypoxia, age, sex, and TB treatment status as a time-dependent variable to adjust for treatment delay. This evidence concerns the gene CD4 and tuberculosis.