Protein tyrosine phosphatase receptor type C (PTPRC), a subgroup of Protein tyrosine phosphatases, which plays a major role in regulation of cell-signalling and controls cell growth, differentiation, apoptosis, survival, migration and invasion [35] was majorly altered in the AML which is an essential regulator of T and B cell antigen receptor-mediated activation [36]. The gene discussed is PTPRC; the disease is acute myeloid leukemia.