For example, OGDH directly binds the histone acetyltransferase KAT2A and generates succinyl-CoA, which is used by KAT2A to succinylate H3K79, and enhance transcription and tumor proliferation in glioma and HEK293 cell lines (Figure 2) (Wang et al., 2017). The gene discussed is KAT2A; the disease is central nervous system cancer.