BGN and type 2 diabetes mellitus: Immunohistochemical results further showed that protein expression involving tissue repair (type I collagen), scar formation (Biglycan), angiogenesis (VIII), and extracellular matrix remodeling marker (MMP-3) was increased in the tendon tissue of rats with type 2 diabetes (Figures 3B, 4A–C), and optical density values (OD) were significantly increased compared with the non-diabetic group (Figures 5A–D).