The only covariates with SMDs above the minimum threshold of 0.2 were inclusion year, diabetes duration, obesity, and previous use of DPP-4is, GLP-1 RAs, insulins, and sulfonylureas; with previous use of GLP-1 RAs exhibiting an SMD of 0.835. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.