GLP1R and obesity due to melanocortin 4 receptor deficiency: In addition, those in the GLP-1 RA group were more likely to have a history of obesity (41.6% vs. 26.6%, SMD 0.321) and had a slightly larger fraction of subjects included in the years 2010-2012 and 2018 and a smaller fraction included in the years 2007-2009 compared to the DPP-4i group.