According to the findings of the univariate analysis, OP patients who have higher 25(OH)D, hemoglobin, lymphocyte counts, calcium, high-density lipoprotein levels, or have lower neutrophil counts, monocyte counts, alanine transaminase, β-CTX, P1NP, and ferritin levels, or who have had previous ZOL infusions, are female, with no fractures, with hypertension, and no calcitonin use, and if the season is autumn (October to November) may have less risk of ZOL-induced fever. The gene discussed is GPT; the disease is hypertensive disorder.