CEBPZ and pulmonary fibrosis: In vivo and in vitro studies of bleomycin and tunicamycin (a drug is employed to induce ER stress) have shown that C/EBPζ upregulation can induce alveolar epithelial cell senescence through the ROS/NF-κB pathway, which activates lung fibroblasts mediated by the senescence-associated secretory phenotype, promoting a pulmonary fibrosis pathology [248, 249].