In summary, these existing studies about C/EBPζ in liver fibrosis show that C/EBPζ overexpression in profibrotic cells such as HSCs, fibroblasts, and M2 macrophages can lead to their apoptosis, inhibiting liver fibrosis, while its overexpression in nonprofibrotic cells such as hepatocytes and M1 macrophages can result in their apoptosis, promoting liver fibrosis by activating profibrotic cells. This evidence concerns the gene CEBPZ and Hepatic fibrosis.