P-C/EBPα-S193 upregulation in liver cells increases the formation of C/EBPα-p300 complex, which directly activates the promoters of triglyceride synthesis-related genes (diacylglycerol O-acyltransferase 1/2 (Dgat1/2), acetyl-coenzyme A (Acaca), stearoyl coenzyme A desaturase 1 (Scd1), and Srebp1), resulting in hepatic steatosis and fibrosis [75, 142, 143]. This evidence concerns the gene DGAT1 and fatty liver disease.