CEBPZ and obesity due to melanocortin 4 receptor deficiency: Accumulating evidence has shown that C/EBPζ expression is upregulated in fibrotic kidney tissues from patients with chronic kidney diseases and obesity, and in animal models of kidney injury, C/EBPζ deficiency attenuates renal fibrosis in mouse model UUO, Ang II/deoxycorticosterone acetate/salt, and diabetic nephropathy [279, 282–285].