Activated C/EBPβ not only directly increases the transcription of Trib3 and Gsk-3b, thereby establishing a positive feedback loop in macrophages, but also enhances the expression of its targeted genes (Arg1, Il10, Tgfb1, and Fizz1) to promote a profibrotic macrophages (M2) phenotype and lung fibrosis [42, 214, 215]. The gene discussed is ARG1; the disease is pulmonary fibrosis.