ADAM17 and pulmonary fibrosis: As a mediator of lung fibrosis activation, hypoxia can promote C/EBPβ phosphorylation at Thr266 (Thr217 in mice), which enhances its binding to a disintegrin and metalloproteinase 17 (ADAM17) promoter and ultimately induces ADAM17 expression in human lung fibroblasts [204].