Collectively, the current study is the first to report that gestational (F0 generation) LPS exposure could augment age-related anxiety-like behavioral changes in both F1 and F2 generations, and these effects were possibly related to decreased Fabp7 expression in the hippocampus, but we were not able to determine more conclusively the link between FABP7 and anxiety-like behaviors in the present study, further exploration is needed in the future. Here, FABP7 is linked to Anxiety.