In this study, we investigated: (a) whether gestational LPS exposure in the F0 generation could augment anxiety-like behaviors and hippocampal FABP7 expression levels alterations in F1 and F2 offspring in adolescence and midlife; (b) whether the differences in anxiety phenotypes and FABP7 expression of F2 offspring originate from F1 paternal or maternal lines; and (c) the association between anxiety-like behaviors and FABP7 expression. This evidence concerns the gene FABP7 and Anxiety.