IL6 and intervertebral disk degenerative disorder: Additionally, macrophages and cytokines also played important roles in inflammatory response through various signaling pathways, providing a great number of targets to treat IDD including JAK inhibitors, IKK-β selective inhibitor and humanized monoclonal antibody against human IL-6 andIL-17 receptors, etc. However, the drug treatment of IDD based on the targets mentioned above remained little studied, thus there is still a long way to go to comprehensively explore the potential values of these drugs in the treatment of IDD.