Of these, the former, together with miR-17 and fibronectin, constitutes a regulatory network involved in renal fibrosis (Xie et al., 2016), while the latter is mainly regulated by the miR-181a-5p/TGF-βR1 signaling pathway and knock out PVT1 can inhibit renal fibrosis (Cao L. et al., 2020). The gene discussed is PVT1; the disease is renal fibrosis.