The protective effect of NF-κB inhibition on renal injury in mice with SLE may be related to lncRNA TUG1 and the inhibition of apoptosis and release of inflammatory factors, thus protecting HK-2 cells from lipopolysaccharide (LPS)-induced inflammatory injury (Cao H. Y. et al., 2020). The gene discussed is TUG1; the disease is systemic lupus erythematosus.