The lncRNA segment H19 functional molecule is involved in the regulation of the high motor group box 1/Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-ĸB) cell signaling pathway, and the expression of the lncRNA H19 was significantly correlated with oxidative stress, mineralization (phosphorus, parathyroid hormone, organic carbon), and inflammatory markers such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in CKD patients (Fan et al., 2019; Okuyan et al., 2021). This evidence concerns the gene TNF and chronic kidney disease.