It was reported that the interaction of IBDV VP2 with heat shock protein 90 (HSP90AA1) induced autophagy through the HSP90AA1-AKT-mTOR pathway early during infection, and the activated autophagy inhibited virus replication (Figure 1), suggesting that autophagy is involved in host defense against IBDV infection [105]. Here, HSP90AA1 is linked to infection.