When we divided the samples into “responder” and “non-responder” groups based on this observation and examined the inhibitory effect of IFN-γ, we observed dose-dependent decreases in infection with IFN-γ treatment in responder samples while non-responder samples showed a modest increase (above 100% of control) in KSHV infection with IFN-γ treatment (Figure 1d). The gene discussed is IFNG; the disease is infection.