In infectious diseases: virus pathway, MYC, JUN, FOS, HSPA2, NFKBIA, CCL4 and EGR1 were significantly up-regulated in the KO IFNAR1 group, while in the DF-1 group, IRF7, IRF1, MX1, TRIM25, RSAD2, IL6, OASL and IFNW1 were significantly up-regulated (Figure S4D). The gene discussed is TRIM25; the disease is infectious disease.