Bengue and collaborators’ studies on the human brain cells revealed the modulation of the immune gene expression profile in MAYV-infected astrocytes, analyzed at 48 hpi (hours post-infection) that PRRs (pattern recognition receptors) such as TLRs are present in brain cells, and the expression of TLR3, and not TLR7 (as for CHIKV infection), was found to be upregulated by MAYV, they also observed a strong induction of the PRRs IFIH1 and DDX58 transcripts by MAYV infection. The gene discussed is RIGI; the disease is infection.