CDK1 and infection: Comparatively, proteomic profiles of WRL-68 cells (a human hepatic cell line) by 2-DGE and MALDI-TOF/TOF (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry) during early infection by CHIKV revealed alteration in the expression of proteins related to mRNA processing and translation, energy and cellular metabolism, ubiquitin-proteasome pathway (UPP), and cell cycle regulation, with cyclin-dependent kinase 1 (CDK1) regulation for efficient viral replication, survival and transmission [91].