Alem and collaborators demonstrated that exosomes released from RVFV infected cells (Exi-RVFV) containing sequences of the viral genome but lacking the L polymerase (RdRp) or the NSs protein play a protective role against infection by inducing the RIG-I dependent activation of IFN expression leading to autophagy of infected cells in order to resist subsequent viral dissemination [142]. The gene discussed is RIGI; the disease is infection.