During infection, RVFV inhibits host cellular RNA synthesis through NSs protein targeting of the transcription factor TFIIH, decreasing its cellular concentration by interacting with its p44 and XPB subunits, inhibiting TFIIH subunits assembly and formation as a means of evading host response, as TFIIH is crucial for host transcription (Figure 7) [129]. This evidence concerns the gene ERCC3 and infection.