The findings included some commonly known proteins involved in arthralgia and arthritis (i.e., MAEA; NEFL; FLG as well as COL23A1—collagen alpha 1 XXIII chain; DMGDH—dimethylglycine dehydrogenase and PDE3A—cGMP-inhibited 3′,5′-cyclic phosphodiesterase A) and also in cell death (such as USP30—ubiquitin carboxy-terminal hydrolase 30) [97]. Here, PDE3A is linked to arthritic joint disease.