Although no significant differences were found when comparing gene expression based on patients’ sex (Figure 2C(i) and Supplementary Figure S4B), the expressions for the following genes belonging to the IFN-γ canonical pathway, decreased with age in COVID-19-positive patients: IFNG (p-trenddecreasing = 0.002), IFNGR2 (p-trenddecreasing = 0.04), JAK1 (p-trenddecreasing = 0.002), JAK2 (p-trenddecreasing = 0.002) and STAT1 (p-trend decreasing = 0.002) (Figure 2C(ii), right panel). This evidence concerns the gene IFNGR2 and COVID-19.