STAT1 and COVID-19: Interestingly, although JAK2 and STAT1, two of the main genes involved in the IFN-γ canonical pathway, presented a positive and significant correlation for non-COVID19 (r = 0.390, p < 0.01), this correlation was significantly increased in COVID-19-positive patients (r = 0.82, p < 0.001) patients (Figure 3A).