Other hallmarks contributing to ABC DLBCL pathogenesis involve chromosomal translocations in the B-cell lymphoma 6 (BCL6) gene, the overexpression of interferon regulatory factor 4 (IRF4), the amplification of Bcl-2 protein and other factors [13,15,17,20,21,22,23,24]. Here, IRF4 is linked to diffuse large B-cell lymphoma.