These results confirmed that lncRNA−MSTRG.16919.1 was a multifunctional lncRNA, which participated in apoptosis by BIRC6, pyroptosis by SCAF11, tumor suppressor and metabolic regulator using PTEN, formation of nuclear pore complexes using RANBP2, viral infection and cellular immunity using SKIV2L2, JAK2, PIK3CB and MAPK8. This evidence concerns the gene PTEN and viral infectious disease.