The key genes from the protein interaction data obtained from string by Degree algorithm in Cytoscape software were screened and the top 20 genes obtained by combined score, including BIRC6, PTEN, PIK3CA, RANBP2, SCAF11, TRIP12, STAG2, BTAF1, ATAD2B, PDS5A, USP34, SKIV2L2, LTN1, CLTC, CEP350, KDM6A, JAK2, DMXL1, PIK3CB and MAPK8, among which SKIV2L2, JAK2, PIK3CB and MAPK8 were related to virus infection. The gene discussed is MTREX; the disease is viral infectious disease.