To investigate whether KSHV transcripts generated within the cells during viral reactivation can also affect host innate immune response, THP-1 cells derived from an acute monocytic leukemia were transfected with plasmids encoding candidate IE and E KSHV genes identified from our RIPseq dataset (Figure 6), and type I interferon (IFN) production was assessed. Here, IFNA1 is linked to acute monocytic leukemia.