She had severe macrocytic anemia (Hb 5.8 [11.8–14.6 g/dL]); thrombocytopenia (Plt 7 [150–360 × 109/L]); conjugated hyperbilirubinemia, raised reticulocyte counts and LDH, low haptoglobin, hypocomplementemia, and mildly raised troponin I. No schistocytes were seen on the peripheral blood film. The gene discussed is HP; the disease is macrocytic anemia.